Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | CRC cell lines, namely, SW480, HCT116, Lovo, CaCO-2, and HT29, and human embryo intestinal mucosal tissue-sourced cell line (i.e., CCC-HIE-2), cancer tissues and noncancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | there was a high potential for highly expressed SNHG1 and lowly expressed miR-497/miR- 195 to symbolize CRC patients` unfavorable prognosis (p < .05). Concurrently, CRC cells were detected with higher SNHG1 expression and lower miR-497/miR-195 expression than CCC-HIE-2 cells (p < .05). In addition, the EMT process of CRC cells was facilitated markedly against the contexts of overexpressed SNHG1 and underexpressed miR-497-5p/miR-195-5p. Intriguingly, the strength of miR-195-5p collaborating with miR-497-5p in affecting the activity of CRC cells seemed to overweigh that of miR-497/miR-195-5p alone. Besides, both miR-195-5p and miR- 497-5p were subjected to in vivo and in vitro modification of SNHG1 (p < .05). |
| Pubmed ID | 31276207 |
| Year | 2019 |
| Title | lncRNA SNHG1 cooperated with miR-497/miR-195-5p to modify epithelial-mesenchymal transition underlying colorectal cancer exacerbation |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |