Basic Information
| LncRNA/CircRNA Name | SNHG1 |
| Synonyms | SNHG1, LINC00057, NCRNA00057, U22HG, UHG, lncRNA16 |
| Region | GRCh38_11:62851988-62855914 |
| Ensemble | ENSG00000255717 |
| Refseq | NR_003098 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | colorectal cancer tissues, cell lines (CCC-HIE-2,SW480, HCT116, HT-29, LOVO, CaCO-2) |
| Expression Pattern | up-regulated |
| Function Description | SNHG1 expression levels were upregulated aberrantly in colorectal cancer tissues and colorectal cancer cell lines. patients with high SNHG1 expression level had poorer overall survival (OS) and progression-free survival (PFS) than those with low SNHG1 expression.increased SNHG1 expression was proved to be an independent unfavorable prognostic indicator for CRC.SNHG1 silencing inhibited the growth and metastasis and induced apoptosis of CRC cell lines.SNHG1 may induce the activation of the WNT/B-catenin pathway through regulating B-catenin expression and transcription factor-4 (TCF-4), cyclin D1 and MMP-9. |
| Pubmed ID | 29340086 |
| Year | 2017 |
| Title | Up-regulation of lncRNA SNHG1 indicates poor prognosis and promotes cell proliferation and metastasis of colorectal cancer by activation of the Wnt/B-catenin signaling pathway. |
External Links
| Links for SNHG1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |