Basic Information
| LncRNA/CircRNA Name | SNHG11 |
| Synonyms | NA |
| Region | GRCh38_20:38446578-38450921 |
| Ensemble | ENSG00000174365 |
| Refseq | NR_003239 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | The human CRC cell lines LoVo , SW480 , HCT-116 and SW620, Blood |
| Expression Pattern | down-regulated |
| Function Description | Plasma levels of the four candidate lncRNAs were significantly reduced in post-operative samples compared to pre-operative samples. A panel including these four lncRNAs performed well in distinguishing patient groups with different stages of colon disease, and SNHG11 exhibited the greatest diagnostic ability to identify precancerous lesions and early-stage tumour formation. Mechanistically, high SNHG11 expression promotes proliferation and metastasis by targeting the Hippo pathway. |
| Pubmed ID | 31633800 |
| Year | 2019 |
| Title | Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer |
External Links
| Links for SNHG11 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |