Basic Information
| LncRNA/CircRNA Name | BX357664 |
| Synonyms | NA |
| Region | GRCh38_8:101491168-101491817 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Cell transfection, Western blot, Cell proliferation assay etc. |
| Sample | RCC tissues, cell lines (caki-1, HEK-293T, caki-2) |
| Expression Pattern | down-regulated |
| Function Description | BX357664 was downregulated in RCC. After the upregulation of BX357664, reduced migration, invasion, and proliferation capabilities in RCC cells were detected. Subsequently, upregulating the protein level of TGF-B1 in the presence of BX357664 could rescue the suppression of the malignant behavior mediated by BX357664, indicating that BX357664 attributed its inhibitory role to the suppression of TGF-B1. |
| Pubmed ID | 27806310 |
| Year | 2016 |
| Title | Long noncoding RNA BX357664 regulates cell proliferation and epithelial-to-mesenchymal transition via inhibition of TGF-B1/p38/HSP27 signaling in renal cell carcinoma. |
External Links
| Links for BX357664 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |