Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | NA |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | RT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | carcinoma and adjacent benign tissues ,The 293T cell, renal epithelial HK-2 cell and kidney carcinoma cell lines(A498, 786-0, 769-p, Caki-1, Caki-2 and ACHN) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was aberrantly up-regulated in renal carcinoma both in vivo and in vitro. High expression of SNHG12 associated with poor prognosis. Deficiency of SNHG12 significantly suppressed cell viability, anchorage-independent growth and induced apoptosis. In addition, SNHG12 silencing inhibited migrative and invasive in vitro and xenograft tumor growth in vivo. Mechanistically, SNHG12 modulated HIF1? expression via competing with miR-199a-5p, which consequently contributed to its oncogenic potential. MiR-199a-5p inhibition severely compromised SNHG12 silencing-elicited tumor repressive effects. |
| Pubmed ID | 31114448 |
| Year | 2019 |
| Title | Overexpression of SNHG12 Regulates the Viability and Invasion of Renal Cell Carcinoma Cells Through Modulation of HIF1? |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |