Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | NA |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | doxorubicin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RIP, Dual Luciferase Reporter Assay, Western blot |
| Sample | osteosarcoma tissues, cell lines(MG-63, U2OS, HOS, SAOS-2, hFOB) |
| Expression Pattern | up-regulated |
| Function Description | High expression of SNHG12 was associated with doxorubicin resistance and a poor overall survival in osteosarcoma. dual luciferase reporter and RNA immunoprecipitation assays revealed that miR-320a targeted to SNHG12. knockdown of SNHG12 promoted the DXR-induced apoptosis of MG-63, U2OS and MG-63/DXR cells. |
| Pubmed ID | 30119255 |
| Year | 2018 |
| Title | Long noncoding RNA SNHG12 mediates doxorubicin resistance of osteosarcoma via miR-320a/MCL1 axis. |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |