Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | GC tissues, human gastric cancer cell lines (SGC7901, NCI-N87 and AGS ) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was significantly overexpressed in GC. Additionally, inhibition of SNHG12 in GC cell lines SGC-7901 and AGS suppressed cell growth, colony formation, proliferation and invasion. MicroRNA-320,a putative target gene of SNHG12, was inversely correlated with SNHG12 expression in GC tissues and cell lines. In addition,the present study determined that miR-320 was directly regulated by SNHG12 and suppression of miR-320 expression reversed the inhibitory effects of SNHG12 siRNA on GC cell proliferation and invasion. |
| Pubmed ID | 29207106 |
| Year | 2017 |
| Title | LncRNA SNHG12 regulates gastric cancer progression by acting as a molecular sponge of miR-320. |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |