Basic Information
| LncRNA/CircRNA Name | SNHG12 |
| Synonyms | SNHG12, ASLNC04080, C1orf79, LINC00100, NCRNA00100, PNAS-123 |
| Region | GRCh38_1:28578538-28582983 |
| Ensemble | ENSG00000197989 |
| Refseq | NR_024127 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, RIP, RNA pull-down analysis, Western blot analysis |
| Sample | Primary tumor samples and matched adjacent non-carcinoma tissues, The normal human skin fibroblast HF cell line and the glioma cell lines, ( U87, LN229, U373 and U251 ) |
| Expression Pattern | up-regulated |
| Function Description | SNHG12 was significantly upregulated in glioma tissues and cell lines.The silencing of SNHG12 expression by RNA interference led to a reduced viability and mobility, and in an increased apoptosis of human glioma cells.SNHG12 was associated with and was stabilized by HuR. |
| Pubmed ID | 30015836 |
| Year | 2018 |
| Title | Long non-coding RNA SNHG12 promotes the proliferation and migration of glioma cells by binding to HuR. |
External Links
| Links for SNHG12 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |