Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | cervical cancer tissues and adjacent normal tissues ,bormal endo-cervical epithelial cell line(End1/E6E7) ,cervical cancer cell lines(SW756, SiHa, HeLa) |
| Expression Pattern | up-regulated |
| Function Description | Compared with normal cervical tissues, the expression of SNHG14 was significantly higher in cervical cancer tissues. The prognosis of patients with higher expression of SNHG14 was worse than those with a lower level.A higher expression level of SNHG14 indicated later tumor stage and higher incidence of lymph node metastasis.After knocking down SNHG14, the viability and proliferation ability of SW756 and SiHa cells were remarkably decreased, while cell apoptosis was increased.Knockdown of SNHG14 enhanced the activation of caspases-3, and increased the protein expression of Bax, JAK2 and STAT3, whereas decreased the expression of Bal-2 and Bid. |
| Pubmed ID | 31114991 |
| Year | 2019 |
| Title | LncRNA SNHG14 Promotes the Development of Cervical Cancer and Predicts Poor Prognosis |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |