Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | diffuse Large B-Cell Lymphoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , Microarray , in vitro knockdown etc. |
| Sample | B cell lymphoma tissues and adjacent normal tissues ,human lymphoblastoid B cell (GM12878), human renal epithelial cell (293T), murine DLBCL cell (A20), and human DLBCL cells (OCI-LY7, DB, U2932, and FARAGE) |
| Expression Pattern | up-regulated |
| Function Description | SNHG14 was upregulated in DLBCL and its depletion retarded proliferation, migration and epithelial-to-mesenchymal transition (EMT). Mechanistically, SNHG14 sponged miR-5590-3p to upregulate Zinc finger E-box binding homeobox 1 (ZEB1), and ZEB1 transcriptionally activated SNHG14 and PD-L1 to promote the immune evasion of DLBCL cells. |
| Pubmed ID | 31570691 |
| Year | 2019 |
| Title | LncRNA SNHG14/miR-5590-3p/ZEB1 Positive Feedback Loop Promoted Diffuse Large B Cell Lymphoma Progression and Immune Evasion Through Regulating PD-1/PD-L1 Checkpoint |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for diffuse Large B-Cell Lymphoma | OMIM COSMIC |