Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Trastuzumab | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, ChIP |
| Sample | breast cancer tissues, cell lines (SKBR-3, BT474) |
| Expression Pattern | up-regulated |
| Function Description | RT-qPCR assay showed that SNHG14 was up-regulated in breast cancer tissues and associated with trastuzumab response.Gain- and loss-of-function experiments revealed that overexpression of SNHG14 promotes cell proliferation, invasion and trastuzumab resistance, overexpression of SNHG14 suppressed the trastuzumab-induced cell apoptosis in BT474 parental cells whereas knockdown of SNHG14 enhanced the apoptosis caused by trastuzumab in SKBR-3/Tr cells. |
| Pubmed ID | 30063126 |
| Year | 2018 |
| Title | Long Non-Coding RNA SNHG14 Induces Trastuzumab Resistance of Breast Cancer via Regulating PABPC1 Expression Through H3K27 Acetylation. |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |