Basic Information
| LncRNA/CircRNA Name | SNHG14 |
| Synonyms | NA |
| Region | GRCh38_15:24978583-25419462 |
| Ensemble | ENSG00000224078 |
| Refseq | NR_146177 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Trastuzumab | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR ect. |
| Sample | breast cancer cell lines ( SKBR-3 and BT474) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA?SNHG14 may promote the effect of trastuzumab by targeting the apoptosis regulator Bcl?2 (Bcl?2)/apoptosis regulator BAX (Bax) signaling pathway. Furthermore, the expression level of serum exosomal lncRNA?SNHG14 was upregulated in patients who exhibited resistance to trastuzumab, compared with patients exhibiting a response. |
| Pubmed ID | 30015837 |
| Year | 2018 |
| Title | Exosome-mediated transfer of lncRNA?SNHG14 promotes trastuzumab chemoresistance in breast cancer. |
External Links
| Links for SNHG14 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |