Basic Information
| LncRNA/CircRNA Name | SNHG15 |
| Synonyms | NA |
| Region | GRCh38_7:44983023-44986961 |
| Ensemble | ENSG00000232956 |
| Refseq | NR_003697 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR |
| Sample | prostate epithelial cell line(RWPE) ,prostate cancer cell lines (LNCaP, DU145 and PC3) |
| Expression Pattern | up-regulated |
| Function Description | This study aims to detect the role of lncRNA small nucleolar RNA host gene 15(SNHG15) in human prostate cancer. Using qRT-PCR analysis, we identified the upregulation of SNHG15 in PCa cell lines. Loss-of function assays were conducted to determine the regulatory effect of SNHG15 on PCa cell proliferation, migration and epithelial-mesenchymal transition (EMT). This investigation demonstrated that SNHG15 may serve as a competing endogenous RNA (ceRNA) to regulate miR-338-3p and FKBP1A. |
| Pubmed ID | 30981837 |
| Year | 2019 |
| Title | LncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis. |
External Links
| Links for SNHG15 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |