Basic Information
| LncRNA/CircRNA Name | SNHG15 |
| Synonyms | SNHG15, C7orf40, Linc-Myo1g, MYO1GUT |
| Region | GRCh38_7:44983023-44986961 |
| Ensemble | ENSG00000232956 |
| Refseq | NR_003697 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase Reporter Gene Assay, RNAi, other |
| Sample | LC tissues and cell lins(H1799 and A549 cells) |
| Expression Pattern | up-regulated |
| Function Description | LC patients with stage I-II presented lower expression of SNHG15 than those with stage III-IV. SNHG15 expression was correlated to tumor size, TNM stage, and lymph node metastasis, whereas not correlated to age and sex of LC patients. For in vitro studies, SNHG15 knockdown resulted in viability reduction, cell cycle arrest and reduced migration of LC cells, which were reversed by the microRNA-211-3p knockdown. |
| Pubmed ID | 30402848 |
| Year | 2018 |
| Title | LncRNA SNHG15 promotes proliferation and migration of lung cancer via targeting microRNA-211-3p. |
External Links
| Links for SNHG15 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |