Detail

Basic Information

LncRNA/CircRNA Name	SNHG15
Synonyms	NA
Region	GRCh38_7:44983023-44986961
Ensemble	ENSG00000232956
Refseq	NR_003697

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	hepatocellular carcinoma
ICD-0-3	C22.0
Methods	qPCR, Luciferase reporter assay, RIP
Sample	HCC cell lines (SMMC-7721, Hep3B, HepG2, and Huh-7), normal human LO2 liver cell line, paired tumor and adjacent healthy tissue samples.
Expression Pattern	up-regulated
Function Description	SNHG15 expression was markedly increased, whereas miR-141-3p expression was substantially reduced in HCC cells and tissue samples relative to normal controls. When SNHG15 was knocked down, this resulted in a significant disruption to the proliferation, as well as the invasive and migratory ability of these HCC cells. miR-141-3p was also found to be an SNHG15 target in HCC cells. Furthermore, miR-141-3p inhibitor partially reversed the observed SNHG15 depletion- mediated reduction in HCC proliferation, migration, and invasion. By repressing miR-141-3p, SNHG15 could modulate zinc finger E-box binding homeobox 2 (ZEB2) and E2F transcription factor 3 (E2F3) expression, both of which are miR-141-3p targets.
Pubmed ID	31310393
Year	2019
Title	LncRNA SNHG15 promotes hepatocellular carcinoma progression by sponging miR-141-3p

External Links

Links for SNHG15	GenBank HGNC NONCODE
Links for hepatocellular carcinoma	OMIM COSMIC