Basic Information
| LncRNA/CircRNA Name | SNHG15 |
| Synonyms | SNHG15, C7orf40, Linc-Myo1g, MYO1GUT |
| Region | GRCh38_7:44983023-44986961 |
| Ensemble | ENSG00000232956 |
| Refseq | NR_003697 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | OS tissues, cell lines (143B, U2OS, HOS, MG63, and SaOS2) |
| Expression Pattern | up-regulated |
| Function Description | up-regulation of SNHG15 was inversely correlated with miR-141 expression in OS tissues.SNHG15 could directly interact with miR-141 and regulate its expression.SNHG15 contributes to proliferation, invasion, migration and autophagy in OS by negatively regulating miR-141,providing a new potential target and prognostic biomarker for the treatment of OS. |
| Pubmed ID | 28720111 |
| Year | 2017 |
| Title | LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR-141. |
External Links
| Links for SNHG15 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |