Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | small nucleolar RNA host gene 16 |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western blot |
| Sample | Tumor specimens,cell lines (A549, NCI-H292, NCI-H460, NCI-H1703,16HBE) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of SNHG16 inhibited NSCLC cell proliferation, migration, invasion and induced apoptosis in vitro as well as suppressed tumor growth in vivo. SNHG16 directly interacted with miR-520a-3p. EphA2 was a target of miR-520a-3p. SNHG16 could regulate the expression of EphA2 by binding to miR-520a-3p. SNHG16 promoted NSCLC development by regulating the miR-520a-3p/EphA2 axis. |
| Pubmed ID | 31953899 |
| Year | 2020 |
| Title | LncRNA SNHG16 Promotes Non-Small Cell Lung Cancer Development Through Regulating EphA2 Expression by Sponging miR-520a-3p |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |