Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | NA |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Dual luciferase reporter assay, RT-qPCR, , Western blotting |
| Sample | pancreatic ductal epithelial cell line HPDE6-C7, human pancreatic carcinoma cell lines PANC-1, AsPC-1, BxPC-3, SW1990 and human embryonic kidney 293 (HEK-293) cells |
| Expression Pattern | up-regulated |
| Function Description | Both the knock down of lncRNA SNHG16 and SREBP2 and overexpression of miR-195 suppressed the proliferation, migration, invasion and lipogenesis in pancreatic cancer cells. LncRNA SNHG16 directly sponged miR-195 to modulate the lipogenesis via regulating the expression of SREBP2. |
| Pubmed ID | 31664866 |
| Year | 2019 |
| Title | LncRNA SNHG16 Induces the SREBP2 to Promote Lipogenesis and Enhance the Progression of Pancreatic Cancer |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |