Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | T Lymphocytes | Survival | ||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, RNAi, other |
| Sample | ALL tissues and cell lines, MOLT3, MOLT4, SUP-B15, CCRF-CEM, RS4, 11,TALL104, CEM/C1, CEM/C2, and Loucy cells |
| Expression Pattern | up-regulated |
| Function Description | Epigenetic regulation of SNHG16 on human miR-124-3p (hsa-miR-124-3p) was evaluated by dual-luciferase activity assay and qPCR. Hsa-miR-124-3p was inhibited in SNHG16-downregulated MOLT3 and SUP-B15 cells to further evaluate the functional correlation between SNHG16 and hsa-miR-124-3p in ALL. SNHG16 is upregulated in both in vitro ALL cell lines and in vivo human leukemic T-cells. SNHG16 downregulation suppressed ALL proliferation and migration in vitro, and ALL explant in vivo. Hsa-miR-124-3p was demonstrated to interact with SNHG16, and upregulated in SNHG16-downregulated ALL cells |
| Pubmed ID | 30380185 |
| Year | 2019 |
| Title | Long non-coding RNA SNHG16 has Tumor suppressing effect in acute lymphoblastic leukemia by inverse interaction on hsa-miR-124-3p. |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for acute lymphoblastic leukemia | OMIM COSMIC |