Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR |
| Sample | gastric cancer tissues, cell lines (AGS, BGC-823, MGC-803, 83 SGC-7901, and MKN451,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA SNHG16 in GC tissue,significantly associated with invasion depth, lymph node metastasis, TNM stage and histological differentiation.Transfected with siRNA of lncRNA SNHG16 inhibited GC MGC-803 cell proliferation, and arrested cells in the G0/G1 phase, and then promoted apoptosis rate with reduced cell invasion and shortened migration distance.LncRNA SNHG16 is highly expressed in GC, while suppression of SNHG16 expression can inhibit proliferation, weaken invasion and migration of GC cells, and enhance apoptosis, to be a novel target for GC clinical treatment. |
| Pubmed ID | 29081409 |
| Year | 2017 |
| Title | Enhanced expression of the long non-coding RNA SNHG16 contributes to gastric cancer progression and metastasis |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |