Basic Information
| LncRNA/CircRNA Name | SNHG16 |
| Synonyms | SNHG16, Nbla10727, Nbla12061, ncRAN |
| Region | GRCh38_17:76557766-76565348 |
| Ensemble | ENSG00000163597 |
| Refseq | NR_038108 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Flow Cytometry, Luciferase Assay, etc. |
| Sample | ESCC tissues, cell lines (TE-13, TE-1,EC-1, Eca-109, HEEC) |
| Expression Pattern | up-regulated |
| Function Description | Kaplan-Meier assay showed that the survival time of patients with high SNHG16 expression was significantly shorter than those with low SNHG16 expression (p = 0.0017). Loss-of-function experiments revealed that knockdown of SNHG16 suppressed proliferation and invasion and induced apoptosis of ESCC cells. Mechanistically, Wnt/B-catenin signaling pathways were actively modulated by SNHG16 in ESCC cells. |
| Pubmed ID | 29949155 |
| Year | 2018 |
| Title | LncRNA SNHG16 predicts poor prognosis in ESCC and promotes cell proliferation and invasion by regulating Wnt/?-catenin signaling pathway. |
External Links
| Links for SNHG16 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |