Basic Information
| LncRNA/CircRNA Name | SNHG17 |
| Synonyms | NA |
| Region | GRCh38_20:38420588-38435353 |
| Ensemble | ENSG00000196756 |
| Refseq | NR_015366 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RNA-seq, qPCR, Western blot, RNAi |
| Sample | The human NSCLC cell lines (A549 and PC-9), cancers and nontumorous tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA Small Nucleolar RNA Host Gene 17 (SNHG17) was upregulated in NSCLC driven by the amplification of copy number, indicating the special role of SNHG17 in NSCLC.Results showed that the knockdown of SNHG17 inhibited the proliferation and migration and promoted the apoptosis of NSCLC cells. We found 637 genes were upregulated while 581 genes were downregulated. We selected three genes (FOXA1, XAF1, and BIK) that were closely related to proliferation and apoptosis, and we confirmed their altered expression in A549 and PC-9 cells treated with small interfering RNA si-SNHG17. |
| Pubmed ID | 31310946 |
| Year | 2019 |
| Title | Gene Amplification-Driven Long Noncoding RNA SNHG17 Regulates Cell Proliferation and Migration in Human Non-Small-Cell Lung Cancer |
External Links
| Links for SNHG17 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |