Basic Information
| LncRNA/CircRNA Name | C17orf91 |
| Synonyms | MIR22HG, C17orf91 |
| Region | GRCh38_17:1711493-1717174 |
| Ensemble | ENSG00000186594 |
| Refseq | NR_028502 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, RNAi, Western blot, Cell migration and invasion assay etc. |
| Sample | cell lines (Hey, 293T) |
| Expression Pattern | up-regulated |
| Function Description | Elevated expression of C17orf91 was observed in omental metastases when compared with matched primary ovarian tumors. Loss-of-function studies further demonstrated that C17orf91 repression impaired migration, invasion and viability of ovarian cancer cells, and downregulated the pro-metastatic gene, MYC, at both mRNA and protein level. |
| Pubmed ID | 27535740 |
| Year | 2016 |
| Title | Long noncoding RNA C17orf91 is a potential prognostic marker and functions as an oncogene in ovarian cancer. |
External Links
| Links for C17orf91 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |