Basic Information
| LncRNA/CircRNA Name | SNHG20 |
| Synonyms | SNHG20, C17orf86, LINC00338, NCRNA00338, SCARNA16HG |
| Region | GRCh38_17:77086716-77094990 |
| Ensemble | ENSG00000234912 |
| Refseq | NR_027058 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | gastric cancer cell lines (Bgastric cancer823, Sgastric cancer-7901, MKN45), hepatocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Thus, the results showed that SNHG20 acted as an oncogene in GC and targeting SNHG20 may serve as a therapeutic target for GC. The western-blotting results showed that knockdown of SNHG20 significantly inhibited the expression levels of transcription factor Twist1 and EMT maker Vimentin, but upregulating the E-cadherin expression in MKN45 cells.LncRNAs could regulated cancer cells phenotypes through regulating target gene expression by different mechanisms, including chromatin modification, genomic imprinting, RNA decay and sponging miRNAs [20]. |
| Pubmed ID | 29113337 |
| Year | 2017 |
| Title | Long noncoding RNA SNHG20 promotes gastric cancer progression by inhibiting p21 expression and regulating the GSK-3B/ B-catenin signaling pathway. |
External Links
| Links for SNHG20 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |