Basic Information
| LncRNA/CircRNA Name | SNHG20 |
| Synonyms | SNHG20, C17orf86, LINC00338, NCRNA00338, SCARNA16HG |
| Region | GRCh38_17:77086716-77094990 |
| Ensemble | ENSG00000234912 |
| Refseq | NR_027058 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RNAi, Western blot, RIP, CCK-8 assay etc. |
| Sample | HCC tissues, cell lines (MHCC97L, SMCC-7721, MHCC97H and Huh-7) |
| Expression Pattern | up-regulated |
| Function Description | SNHG20 was significantly up-regulated in HCC tissues. In vitro, loss-function assays revealed that knockdown of SNHG20 inhibited cell proliferation and invasion, whereas, gain-of-function promoted cell proliferation and invasion. Furthermore, knockdown of SNHG20 inhibited ZEB1, ZEB2, N-cadherin and Vimentin expression and up-regulated the E-cadherin expression in HCC cells. Mechanistic investigation revealed that SNHG20 could bind to enhancer of zeste homolog 2 (EZH2) and regulated E-cadherin expression. |
| Pubmed ID | 28282787 |
| Year | 2017 |
| Title | Long non-coding RNA SNHG20 predicts a poor prognosis for HCC and promotes cell invasion by regulating the epithelial-to-mesenchymal transition. |
External Links
| Links for SNHG20 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |