Basic Information
| LncRNA/CircRNA Name | SNHG3 |
| Synonyms | NA |
| Region | GRCh38_1:28505980-28510892 |
| Ensemble | ENSG00000242125 |
| Refseq | NR_002909.1 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Real-Time QPCR, Western blot, Luciferase Reporter Assay |
| Sample | MCF-7 and MD-MBA-453 breast cancer cells |
| Expression Pattern | up-regulated |
| Function Description | CAF-Secreted Exosomal SNHG3 Promoted Proliferation and Downregulated Mitochondrial Role in Breast Tumor Cells.CAF-Secreted Exosomal SNHG3 Regulates the miR-330 Expression in Breast Tumor Cells.Knockdown of CAF-Secreted Exosomal SNHG3 Inhibited Breast Cancer Cell Proliferation Through Increasing miR-330 and Decreasing PKM Expression. |
| Pubmed ID | 31956955 |
| Year | 2020 |
| Title | SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming |
External Links
| Links for SNHG3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |