Basic Information
| LncRNA/CircRNA Name | SNHG3 |
| Synonyms | NA |
| Region | GRCh38_1:28505980-28510892 |
| Ensemble | ENSG00000242125 |
| Refseq | NR_002909.1 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | NSCLC tissues and matched normal tissues ,mouse NSCLC cell lines (CMT-167, LLC, CMT-170, and CMT-181), normal mouse lung epithelial cells (MLE12) |
| Expression Pattern | up-regulated |
| Function Description | We detected the upregulated expression of SNHG3 in NSCLC tissues as well as cells.high-level of SNHG3 was associated with a low overall survival rate of patients with NSCLC.SNHG3 had a significantly positive effect on NSCLC cell proliferation and migration.SNHG3 was a predicted direct transcriptional target of E2F1. We observed that the transcriptional activation of SNHG3 could be induced by E2F1.The cotreatment with SB-431542, JSI-124, or JSI-124 + SB-431542 rescued the effects brought by the overexpression of SNHG3 on NSCLC cell proliferation, migration, and epithelial-mesenchymal transition process. |
| Pubmed ID | 31602642 |
| Year | 2019 |
| Title | LncRNA SNHG3 Is Activated by E2F1 and Promotes Proliferation and Migration of Non-Small-Cell Lung Cancer Cells Through Activating TGF-? Pathway and IL-6/JAK2/STAT3 Pathway |
External Links
| Links for SNHG3 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |