Basic Information
| LncRNA/CircRNA Name | SNHG3 |
| Synonyms | NA |
| Region | GRCh38_1:28505980-28510892 |
| Ensemble | ENSG00000242125 |
| Refseq | NR_002909.1 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | breast cancer and paired adjacent normal tissues , human breast cancer cell lines(MDA-MB-231 and MCF-7) and the immortalized breast epithelial cell line MCF-10A |
| Expression Pattern | up-regulated |
| Function Description | SNHG3 was upregulated and associated with tumour malignancy in patients with breast cancer. SNHG3 knockdown inhibited the growth and metastatic capabilities of breast cancer cells in vitro and vivo.SNHG3 upregulation inhibited miR-384 activity and led to hepatoma-derived growth factor (HDGF) overexpression in breast cancer cells. |
| Pubmed ID | 31586299 |
| Year | 2019 |
| Title | LncRNA SNHG3 Promotes Cell Proliferation and Invasion Through the miR-384/hepatoma-derived Growth Factor Axis in Breast Cancer |
External Links
| Links for SNHG3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |