Basic Information
| LncRNA/CircRNA Name | SNHG3 |
| Synonyms | SNHG3, NCRNA00014, RNU17C, RNU17D, U17HG, U17HG-A, U17HG-AB |
| Region | GRCh38_1:28505980-28510892 |
| Ensemble | ENSG00000242125 |
| Refseq | NR_002909.1 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, other |
| Sample | AML tissues and cell lines (HL-60, THP-1, KG-1, NB4, MOLM-14) |
| Expression Pattern | up-regulated |
| Function Description | Furthermore, knockdown of SNHG3 or SRGN inhibited cell proliferation and induced cell apoptosis. Besides, silencing SNHG3 noticeably decreased the expression of SRGN in AML cells. Moreover, we uncovered that SNHG3 modulated SRGN expression by competitively binding with miR-758-3p. Importantly, both miR-758-3p suppression and SRGN overexpression could mitigate the inhibitory effects of SNHG3 depletion on AML cell growth. Intriguingly, the higher SRGN expression in AML samples with a higher SNHG3 level exhibited an enhanced Ki67 level but a reduced caspase 3 level. |
| Pubmed ID | 31452272 |
| Year | 2020 |
| Title | lncRNA SNHG3 Facilitates Acute Myeloid Leukemia Cell Growth via the Regulation of miR-758-3p/SRGN Axis |
External Links
| Links for SNHG3 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |