Basic Information
| LncRNA/CircRNA Name | AC023115.3 |
| Synonyms | NA |
| Region | GRCh38_2:67324627-67325304 |
| Ensemble | ENSG00000236605 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, westen blot, Microarray etc. |
| Sample | cell lines (U87MG and U251MG) |
| Expression Pattern | down-regulated |
| Function Description | AC023115.3 was preferentially enriched in the Ago2-containing microRNA ribonucleoprotein complexes (miRNPs) compared with the immunoprecipitates with control IgG,indicating that AC023115.3 is present in the Ago2-containing miRNPs likely through an association with microRNAs. AC023115.3 was induced by cisplatin and suppressed glioma chemoresistance.AC023115.3 inhibited cisplatin-induced autophagy. AC023115.3 promoted cisplatin-induced apoptosis via decreasing autophagy. AC023115.3 acted as a miR-26a sponge and inhibited its activity. AC023115.3 sensitized glioma cell to cisplatin-induced apoptosis through regulation of the miR-26a-GSK3B-Mcl1 signalling. |
| Pubmed ID | 28499919 |
| Year | 2017 |
| Title | Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy |
External Links
| Links for AC023115.3 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |