Basic Information
| LncRNA/CircRNA Name | SNHG4 |
| Synonyms | NA |
| Region | GRCh38_5:139274102-139283477 |
| Ensemble | ENSG00000281398 |
| Refseq | NR_003141 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | CC tissues and adjacent normal cervical tissues ,human normal cervical epithelial cells (NCEC) ,human cervical cancer cell lines (c4-1, Caski, HeLa, SiHa) |
| Expression Pattern | up-regulated |
| Function Description | The expression of SNHG4 was increased in both CC cell lines and tissues, while the expression of miR-148a-3p was down-regulated. Meanwhile, silencing SNHG4 remarkably inhibited CC cell proliferation and promoted apoptosis.In addition, miR-148a-3p was a direct target gene of SNHG4, and down-regulation of miR-148a-3p could observably reverse the effect of silencing SNHG4 on the proliferation and apoptosis of CC cells.SNHG4 could up-regulate the expression of c-Met by targeting and interacting with miR-148a-3p. Finally, silence SNHG4 down-regulated the expression of c-Met by promoting miR-148a-3p, and ultimately suppressed the growth of CC tumor in vivo. |
| Pubmed ID | 31590627 |
| Year | 2019 |
| Title | Long Non-Coding RNA?SNHG4?Promotes Cervical Cancer Progression Through Regulating c-Met via Targeting miR-148a-3p |
External Links
| Links for SNHG4 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |