Basic Information
| LncRNA/CircRNA Name | SNHG5 |
| Synonyms | NA |
| Region | GRCh38_6:85660950-85678736 |
| Ensemble | ENSG00000203875 |
| Refseq | NR_003038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | bone marrow tissues,cell lines (HS-5 , HL-60, KG-1a,Kasumi-1, ME-1, and MOLM-14) |
| Expression Pattern | up-regulated |
| Function Description | QRT-PCR was used to investigate the expression of SNHG5, miR-489-3p, and SOX. The proliferation and apoptosis of AML cells were analyzed by cell transfection, cell counting kit-8 (CCK8), and flow cytometric analysis. Moreover, the expression analysis of marker proteins was detected by western blot. Through luciferase activity assay, RNA pull-down, and RNA-binding protein immunoprecipitation (RIP), we proved that SNHG5 could bind miR-489-3p and SOX4 which might be the target gene of miR-489-3p. |
| Pubmed ID | 32266420 |
| Year | 2020 |
| Title | LncRNA SNHG5 Regulates SOX4 Expression Through Competitive Binding to miR-489-3p in Acute Myeloid Leukemia |
External Links
| Links for SNHG5 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |