Basic Information
| LncRNA/CircRNA Name | SNHG5 |
| Synonyms | small nucleolar RNA host gene 5 |
| Region | GRCh38_6:85660950-85678736 |
| Ensemble | ENSG00000203875 |
| Refseq | NR_003038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter assay, Western blot |
| Sample | brain glial cell line HEB and three human GBM cell lines (U251, U87 and LN229) |
| Expression Pattern | up-regulated |
| Function Description | SNHG5 was highly expressed in GBM. Loss- and gain-of-function assays revealed that SNHG5 promoted GBM cell proliferation and inhibited cell apoptosis in GBM. Mechanism experiments proved Yin Yang 1 (YY1) as transcriptional activator of SNHG5 in GBM. More importantly, we found that SNHG5 played the oncogenic role in GBM by activating p38/MAPK signaling pathway. |
| Pubmed ID | 31657621 |
| Year | 2019 |
| Title | YY1-Activated Long Noncoding RNA SNHG5 Promotes Glioblastoma Cell Proliferation Through p38/MAPK Signaling Pathway |
External Links
| Links for SNHG5 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |