Basic Information
| LncRNA/CircRNA Name | SNHG5 |
| Synonyms | NA |
| Region | GRCh38_6:85660950-85678736 |
| Ensemble | ENSG00000203875 |
| Refseq | NR_003038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | cisplatin-sensitive GC tissues ,cisplatin-resistant GC tissues ,GC cell lines (BGC823 and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | SNHG5 is highly expressed in cisplatin-resistant GC.SNHG5 overexpression reduced cisplatin sensitivity in BGC823 and SGC7901 cells. Decreased cisplatin cytotoxicity, elevated IC50 and inhibited apoptotic rate were observed in GC cells overexpressing SNHG5.SNHG5 promotes cisplatin resistance in GC by regulating apoptosis-related genes and drug resistance-related genes. |
| Pubmed ID | 31173289 |
| Year | 2019 |
| Title | LncRNA SNHG5 Promotes Cisplatin Resistance in Gastric Cancer via Inhibiting Cell Apoptosis |
External Links
| Links for SNHG5 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |