Basic Information
| LncRNA/CircRNA Name | SNHG5 |
| Synonyms | SNHG5, C6orf160, LINC00044, NCRNA00044, U50HG, bA33E24.2 |
| Region | GRCh38_6:85660950-85678736 |
| Ensemble | ENSG00000203875 |
| Refseq | NR_003038 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Northern blot, RIP, Luciferase reporter assay etc. |
| Sample | cell lines (HCT116, LS174T, HT-29) |
| Expression Pattern | up-regulated |
| Function Description | Here, we identify and characterize SNHG5 as a stable cytoplasmic lncRNA with up-regulated expression in colorectal cancer. Depletion of SNHG5 induces cell cycle arrest and apoptosis in vitro and limits tumour outgrowth in vivo, whereas SNHG5 overexpression counteracts oxaliplatin-induced apoptosis. |
| Pubmed ID | 28004750 |
| Year | 2016 |
| Title | SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. |
External Links
| Links for SNHG5 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |