Basic Information
| LncRNA/CircRNA Name | C5orf66-AS1 |
| Synonyms | NA |
| Region | GRCh38_5:135038831-135040047 |
| Ensemble | ENSG00000249082 |
| Refseq | NR_105049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, etc. |
| Sample | cervical cancer tissues, normal cervical epithelial cell line End1/E6E7 and the cervical cancer cell lines SiHa, C-4 I, HeLa and C-33A |
| Expression Pattern | up-regulated |
| Function Description | lncRNAC 5orf66-AS1 was significantly upregulated in cervical cancer tissues and cells. Over-expression of C5orf66-AS1 promoted the proliferation of cervical cancer cells, while downregulation of C5orf66-AS1 promoted the apoptosis of cervical cancer cells. C5orf66-AS1 was identified as the sponge of miR-637 by RNA immunoprecipitation (RIP) and luciferase reporter assays. Exogenous miR-637 and RING1 interventions could reverse the proliferation ability mediated by C5orf66-AS1 in cervical cancer cells. In vivo experiments also confirmed that downregulation of C5orf66-AS1 inhibited the tumour growth. LncRNA C5orf66-AS1, as a competitive endogenous RNA (ceRNA), regulated the effect of RING1 on the proliferation, apoptosis and cell cycle of cervical cancer cells through adsorbing miR-637. |
| Pubmed ID | 30518760 |
| Year | 2018 |
| Title | Long non-coding RNA C5orf66-AS1 promotes cell proliferation in cervical cancer by targeting miR-637/RING1 axis |
External Links
| Links for C5orf66-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |