Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | small nucleolar RNA host gene 6 |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase Reporter Assay |
| Sample | tumor tissues,ESCC cell lines (EC109, EC9706, KYSE30, and KYSE150) and human immortalized esophageal epithelial cell line (SHEE) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA SNHG6 and HIF1? were upregulated, while miR-186-5p was downregulated in ESCC tissues and cell lines. Knockdown of lncRNA SNHG6 inhibits ESCC cell proliferation, migration, and invasion.lncRNA SNHG6 was identified as a decoy for miR-186-5p, thereby promoting the expression of miR-186-5p target HIF1?.restoration of SNHG6 or HIF1? could reverse the inhibitory effect of miR-186-5p on ESCC cell proliferation, migration, and invasion. |
| Pubmed ID | 31853782 |
| Year | 2019 |
| Title | Silencing of Long Noncoding RNA SNHG6 Inhibits Esophageal Squamous Cell Carcinoma Progression via miR-186-5p/HIF1? Axis |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |