Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | CRC tissues and corresponding noncancerous tissues?,human CRC cell lines (SW480, SW620, HCT8, and HT-29) ,human normal colon mucosal epithelial cell line (NCM460) |
| Expression Pattern | up-regulated |
| Function Description | SNHG6 and EZH2 mRNA were upregulated, and miR-26a was downregulated in CRC tissues and cell lines. SNHG6 knockdown suppressed the migration, invasion, and epithelial-mesenchymal transition (EMT) of CRC cells.SNHG6 binded to miR-26a and repressed miR-26a expression. EZH2 was a direct target of miR-26a, and it was regulated by SNHG6/miR-26a.MiR-26a inhibitor undermined the effect of SNHG6 knockdown on cell migration, invasion, and EMT.Additionally, EZH2 antagonized the effect of miR-26a on cell migration, invasion, and EMT in CRC cells. |
| Pubmed ID | 31118686 |
| Year | 2019 |
| Title | LncRNA SNHG6 Promotes the Migration, Invasion, and Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by miR-26a/EZH2 Axis |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |