Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | SNHG6, HBII-276HG, NCRNA00058, U87HG |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RNAi, other |
| Sample | LUAD tissues and cell lines (A549, H1299, H460,HCC827, NCl-H358 and NCl-H1650) |
| Expression Pattern | up-regulated |
| Function Description | In this study, SNHG6 was upregulated in LUAD tissues, and its upregulation was positively associated with advanced TNM stage, large tumour size and poor overall survival (OS) in LUAD patients. Gain- and loss-of-function experiments confirmed that SNHG6 promoted cell cycle progression, cell proliferation, migration and invasion, and epithelial-mesenchymal transition (EMT) in vitro. Animal experiments demonstrated that SNHG6 knockdown remarkably inhibited xenograft formation in vivo. Moreover, mechanistic experiments identified that SNHG6 functions as a competing endogenous RNA (ceRNA) through competitively sponging miR-26a-5p to regulate E2F7 expression, cell motility and EMT in LUAD cells. |
| Pubmed ID | 30257360 |
| Year | 2018 |
| Title | SNHG6 Functions as a Competing Endogenous RNA to Regulate E2F7 Expression by Sponging miR-26a-5p in Lung Adenocarcinoma |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |