Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | The human colon cancer SW480 and HCT-116 cell lines and normal colonic mucosa NCM460 cell line, colon tumors and adjacent non-tumor tissues |
| Expression Pattern | down-regulated |
| Function Description | SNHG6 expres- sion was downregulated in colorectal cancer tissues by reverse transcription quantitative polymerase chain reaction assays; however, ETS1 expression levels were upregulated. Overexpression of SNHG6 not only inhibited the prolifera- tion of colon cancer cells in vitro by inducing apoptosis, but also inhibited cell proliferation, invasion and migration. The overexpression of SNHG6 inhibited colon cell viability and proliferation by targeting ETS1 through the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin signaling pathway. |
| Pubmed ID | 31322251 |
| Year | 2019 |
| Title | LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |