Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Normal hepatic cell line HL-7702 and HCC cell lines including HepG2, Hep3b, HLE and Huh-7, HCC tissue samples and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | the SNHG6 expression level was up-regulated in all four HCC cell lines,In contrast, miR-139-5p was significantly down-regulated in HCC cells, the inhibition of miR139-5p promotes the proliferation of HCC cells, and accelerated the cell cycle of HCC cells. Our study demonstrated the co-expression of SNHG6 and SERPINH1 in HCC cells for the first time, which revealed that SNHG6 could serve as a novel oncogene for the HCC therapy by its regulation. |
| Pubmed ID | 31258024 |
| Year | 2019 |
| Title | Up-regulation of SNHG6 activates SERPINH1 expression by competitive binding to miR-139-5p to promote hepatocellular carcinoma progression |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |