Basic Information
| LncRNA/CircRNA Name | SNHG6 |
| Synonyms | NA |
| Region | GRCh38_8:66921684-66926398 |
| Ensemble | ENSG00000245910 |
| Refseq | NR_002599 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot |
| Sample | Human kidney (Wilms` tumour) cell line G401 and SK-NEP-1, human nephroblastoma tissues and adjacent regular tissues |
| Expression Pattern | up-regulated |
| Function Description | overexpression of SNHG6 was found in WT tissues. The knockdown of SNHG6 suppressed cell proliferation, migration and incursion, but promoted apoptosis. Further study found that the knockdown of SNHG6 elevated the expression of miR-15a. Then, the combination of miR-15a inhibitor abolished the inhibiting effect of si-SNHG6 on WT progression. We also found that the TAK1/JNK and Wnt/b-catenin signal pathways were inactivated by the knockdown of SNHG6 through elevating the expression of miR-15a. |
| Pubmed ID | 31257923 |
| Year | 2019 |
| Title | Silencing long non-coding RNA SNHG6 restrains proliferation, migration and invasion of Wilms` tumour cell lines by regulating miR-15a |
External Links
| Links for SNHG6 | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |