Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot |
| Sample | esophageal Cancer tissues, cell lines (Eca109, EC9706, TE-10, and TE-11) |
| Expression Pattern | up-regulated |
| Function Description | The expression of SNHG7 in esophageal cancer tissues and cells was significantly up-regulated. The up-regulation of SNHG7 was significantly in relation to the risk of lymph node metastasis. After the si-SNHG7 intervention, the proliferation of esophageal cancer cells was inhibited, the apoptosis rate increased, and the cell cycle was blocked in G1-G0 phase. QRT-PCR and Western blot showed that, after the si-SNHG7 intervention, the expression of p15 and p16 increased significantly. |
| Pubmed ID | 29771415 |
| Year | 2018 |
| Title | LncRNA SNHG7 Promotes the Proliferation of Esophageal Cancer Cells and Inhibits Its Apoptosis |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |