Basic Information
| LncRNA/CircRNA Name | CA3-AS1 |
| Synonyms | NA |
| Region | GRCh38_8:85441851-85464915 |
| Ensemble | ENSG00000253549 |
| Refseq | NR_121630 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RT-PCR, Western blot, Luciferase reporter assay, other |
| Sample | Colorectal cancer tissues and cell lines(HCT-116, SW480, SW620, SW1116 and HT29) |
| Expression Pattern | up-regulated |
| Function Description | CA3-AS1 mainly located in cytoplasm, and overexpression of lncRNA CA3-AS1 inhibits cell proliferation, invasion and promotes cell apoptosis. Our results revealed that miR-93 could directly bind to CA3-AS1, and verified the oncogenic role of miR-93. Furthermore, we found that miR-93 played its role through regulating PTEN, the tumor-suppressor gene, which was inversely correlated with miR-93. |
| Pubmed ID | 30415006 |
| Year | 2019 |
| Title | Overexpression of Long Non Coding RNA CA3-AS1 Suppresses Proliferation, Invasion and Promotes Apoptosis via miRNA-93/PTEN Axis in Colorectal Cancer |
External Links
| Links for CA3-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |