Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | Small nucleolar RNA host gene 7 |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Luciferase reporter assay, Western blot |
| Sample | primary tumors,gastric cancer cell lines (MKN-45, SGC7901, N87) and human gastric mucosal epithelial cells (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | the levels of SNHG7 expression in gastric cancer tissues and cell lines were severally higher than in normal adjacent tissues and gastric mucosal epithelial cells. Moreover, high SNHG7 expression was positively correlated with TNM stage, depth of invasion, lymph-node metastasis and distant metastasis in gastric cancer patients.SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through suppressing miR-34a-Snail-EMT axis. |
| Pubmed ID | 31814518 |
| Year | 2020 |
| Title | SNHG7 Accelerates Cell Migration and Invasion Through Regulating miR-34a-Snail-EMT Axis in Gastric Cancer |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |