Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | NA |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | breast cancer tissues and matched adjacent normal tissues ,human breast cancer cell lines (MCF-7, MDA-MB-231, MDA-MB-157, and MDA-MB-435) and normal human mammary gland epithelial cell line (MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | SNHG7 was significantly up-regulated in breast cancer tissues and cell lines. SNHG7 knockdown significantly inhibited MCF-7 cell proliferation and invasion, while SNHG7 overexpression dramatically promoted T47D cell proliferation and invasion.SNHG7 knockdown significantly inhibited tumor growth in mice.miR-34a was confirmed to be the target of SNHG7, and SNHG7 could sponge miR-34a to inhibit the expression of miR-34a.SNHG7 targeted miR-34a and promoted epithelial-to-mesenchymal transition (EMT) initiation and the Notch-1 pathway in breast cancer. |
| Pubmed ID | 31132353 |
| Year | 2019 |
| Title | LncRNA SNHG7 Contributes to Tumorigenesis and Progression in Breast Cancer by Interacting With miR-34a Through EMT Initiation and the Notch-1 Pathway |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |