Basic Information
| LncRNA/CircRNA Name | SNHG7 |
| Synonyms | SNHG7, NCRNA00061 |
| Region | GRCh38_9:136721366-136728184 |
| Ensemble | ENSG00000233016 |
| Refseq | NR_003672 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | Glioblastoma tissue, human GBM cell lines (A172, U87, T98G and SHG44) |
| Expression Pattern | up-regulated |
| Function Description | the expression of SNHG7 was significantly upregulated in GBM tissues and cell lines compared with non-cancerous brain tissues. Furthermore,SNHG7 knockdown remarkably suppressed the proliferation, migration and invasion of A172 and U87-cells while inducing their apoptosis. Subsequently, SNHG7 knockdown significantly inhibited tumor growth and metastasis in-vivo by using xenograft experiments in nude mice.SNHG7 directly inhibited miR-5095,which targeted the 3'UTR of CTNNB1 mRNA and subsequently downregulated the Wnt/B-catenin signaling pathway in GBM. Using rescue experiments, we demonstrated that SNHG7 promoted the proliferation, migration and invasion of GBM cells through the inhibition of miR-5095 and concomitant activation of Wnt/B-catenin signaling pathway. |
| Pubmed ID | 29360452 |
| Year | 2018 |
| Title | Long noncoding RNA SNHG7 promotes the progression and growth of glioblastoma via inhibition of miR-5095. |
External Links
| Links for SNHG7 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |