Basic Information
| LncRNA/CircRNA Name | SNHG8 |
| Synonyms | SNHG8, LINC00060, NCRNA00060 |
| Region | GRCh38_4:118278709-118279823 |
| Ensemble | ENSG00000269893 |
| Refseq | NR_003584 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR etc. |
| Sample | cell lines (GES-1, GT38, GT39, AGS and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | The transcript levels of SNHG8 in the cultured EBV-associated GC cells were significantly higher in the cultured EBV-associated GC cells compared with the levels in normal human gastric mucosal cells and EBV-negative GC cells. Knockdown of SNHG8 with specific shRNAs inhibited cell proliferation and colony formation and arrested the cell cycle in the G0/G1 phase in vitro. We also found that knockdown of SNHG8 suppressed tumor growth in vivo. |
| Pubmed ID | 29736176 |
| Year | 2018 |
| Title | Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma. |
External Links
| Links for SNHG8 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |