Basic Information
| LncRNA/CircRNA Name | SOCS2-AS1 |
| Synonyms | NA |
| Region | GRCh38_12:93542463-93571768 |
| Ensemble | ENSG00000246985 |
| Refseq | NR_038263 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | docetaxel | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR, RIP, ChIP etc. |
| Sample | cell lines (LNCaP, LTAD, VCaP) |
| Expression Pattern | up-regulated |
| Function Description | we identified an androgen-regulated lncRNA, suppressor of cytokine signaling 2-antisense transcript 1 (SOCS2-AS1), the expression of which was higher in castration-resistant prostate cancer model cells, i.e long-term androgen-deprived (LTAD) cells, than in parental androgen-dependent LNCaP cells. SOCS2-AS1 promoted castration-resistant and androgen-dependent cell growth. We found that SOCS2-AS1 knockdown up-regulated genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitized prostate cancer cells to docetaxel treatment. |
| Pubmed ID | 27342777 |
| Year | 2016 |
| Title | Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells. |
External Links
| Links for SOCS2-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |