Basic Information
| LncRNA/CircRNA Name | sONE |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Hydrogen sulphide | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot |
| Sample | cell lines (MDA-MB-231, MCF-7 ) |
| Expression Pattern | NA |
| Function Description | Such intricate cross-talk was found to be orchestrated by the novel lncRNA, sONE and its down-stream target NOS3 building up a novel axis, sONE/NOS3/NO, that was shown to play a pivotal role in plotting the bilateral effect of H2S on TNBC progression. |
| Pubmed ID | 30081213 |
| Year | 2018 |
| Title | A Novel Role of sONE/NOS3/NO Signaling Cascade in Mediating Hydrogen Sulphide Bilateral Effects on Triple Negative Breast Cancer Progression. |
External Links
| Links for sONE | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |